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이트라코나졸(itraconazole)액의 첨가물에 의해 발생한 지연형 두드러기 및 혈관부종 1예
Delayed onset urticaria and angioedema caused by components of itraconazole solution

Allergy Asthma & Respiratory Disease 2014년 2권 2호 p.138 ~ p.141

김수영(Kim Su-Young) - 고신대학교 의과대학 내과학교실
최길순(Choi Gil-Soon) - 고신대학교 의과대학 내과학교실
김희규(Kim Hee-Kyoo) - 고신대학교 의과대학 내과학교실
김제훈(Kim Je-Hun) - 고신대학교 의과대학 내과학교실
김철수(Kim Cheol-Su) - 고신대학교 의과대학 내과학교실
양정욱(Yang Joung-Wook) - 고신대학교 의과대학 내과학교실
유가인(You Ga-In) - 고신대학교 의과대학 내과학교실
이진영(Lee Jin-Young) - 고신대학교 의과대학 내과학교실

Abstract

Itraconazole, new triazole agent with a broader antifungal spectrum than fluconazole, has been prescribed widely in the treatment and prophylaxis for fungal infection. Itaconazole has been reported to have gastrointestinal disturbance (4%) and headache (1%) as its most common side-effects. However, allergic reactions caused by this drug are rare. A 53-year-old woman with myelodysplastic syndrome received prophylactic antibiotic therapy including itraconazole solution before chemotherapy. She complained of hive on the face with angioedema at 6 hours after taking them. The symptoms were more aggravated on the next day and reversed by stopping itraconazole solution and injection of antihistamine and steroids. Skin prick tests with itraconazole solution, itraconazole tablet, and ketoconazole showed all the negative responses. The oral challenge test with itraconazole solution was performed and resulted in urticaria and angioedema 6 hours later. Next, the oral challenge test with intraconazole tablet was performed and showed negative response. The patient was finally diagnosed as adverse reaction by additives contained intraconazole solution. We report, a case of delayed onset urticaria and angioedema caused by components of itraconazole solution.

키워드

Itraconazole, Urticaria, Angioedema, Delayed hypersensitivity

KMID : 1035620140020020138

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ICD 03

건강보험코드

이트라코나졸(itraconazole)액의 첨가물에 의해 발생한 지연형 두드러기 및 혈관부종 1예 Delayed onset urticaria and angioedema caused by components of itraconazole solution

Abstract

키워드

이트라코나졸(itraconazole)액의 첨가물에 의해 발생한 지연형 두드러기 및 혈관부종 1예
Delayed onset urticaria and angioedema caused by components of itraconazole solution